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Micropatterning the Organization of Multicellular Structures in 3D Biological Hydrogels; Insights into Collective Cellular Mechanical Interactions

Bar Ergaz,  Shahar Goren, Ayelet Lesman

Biofabrication. 2023


Inference of long-range cell-cell force transmission from ECM remodeling fluctuations

Assaf Nahum, Yoni Koren, Bar Ergaz, Sari Natan, Gad Miller, Yuval Tamir, Shahar Goren, Avraham Kolel, Sankar Jagadeeshan, Moshe Elkabets, Ayelet Lesman, Assaf Zaritsky

Communications Biology. 2023

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Intercellular Mechanical Signalling in a 3D Nonlinear Fibrous
Network Model 

Ran S. Sopher,  Shahar Goren, Yoni Koren,  Oren Tchaicheeyan, Ayelet Lesman

Mechanics of Materials. 2023

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Probing Local Force Propagation in Tensed Fibrous Gels

Shahar Goren, Maayan Levin, Guy Brand, Ayelet Lesman, Raya Sorkin

Small. 2022

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Strain Gradient Programming in 3D Fibrous Hydrogels to Direct Graded Cell Alignment

Avraham Kolel, Bar Ergaz, Shahar Goren, Oren Tchaicheeyan, Ayelet Lesman

Small Methods. 2022


Does the Extracellular Matrix Support Cell-Cell Communication by Elastic Wave Packets?

Artem Y. Panchenko, Oren Tchaicheeyan, Igor E. Berinskii, Ayelet Lesman

ACS Biomaterials and Engineering. 2022

Seaweed Cellulose Scaffolds Derived from Green Macroalgae for Tissue Engineering

Nurit Bar-Shai, Orna Sharabani-Yosef, Meiron Zollmann, Ayelet Lesman, Alexander Golberg

Scientific Reports. 2021


FITC-Dextran Release from Cell-Embedded Fibrin Hydrogels

Viki Raz Lepsky, Sari Natan, Oren Tchaicheeyan, Avraham Kolel, Merav Zussman, Meital Zilberman, Ayelet Lesman

Biomolecules. 2021

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Controlled Strain of 3D Hydrogels under Live Microscopy Imaging

Avraham Kolel, Avishy Roitblat Riba, Sari Natan, Oren Tchaicheeyan, Eilom Saias, Ayelet Lesman

Journal of Visualized Experiments. 2020

Target Finding in Fibrous Biological Environments

David Gomez, Eial Teomy, Ayelet Lesman, Yair Shokef

New Journal of Physics. 2020

Motion Magnification Analysis of Microscopy Videos of Biological Cells

Oren Shabi, Sari Natan, Avraham Kolel, Abhishek Mukherjee, Oren Tchaicheeyan, Haguy Wolfenson, Nahum Kiryati, Ayelet Lesman

 PLOS ONE. 2020

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Coral-derived Collagen Fibers for Engineering Aligned Tissues

Ortal Shelah, Shir Wertheimer, Rami Haj-Ali, Ayelet Lesman

 Tissue Engineering Part A. 2020

Long-range Mechanical Coupling of Cells in 3D Fibrin Gels

Sari Natan, Yoni Koren, Ortal Shelah, Shahar Goren, Ayelet Lesman

Molecular Biology of the Cell. 2020


Elastic Anisotropy Governs the Range of Cell-Induced Displacements

Shahar Goren, Yoni Koren, Xinpeng Xu, Ayelet Lesman

Biophysical Journal. 2020


Straining 3D Hydrogels with Uniform Z-Axis Strains While Enabling Live Microscopy Imaging

Avishy Roitblat Riba, Sari Natan, Avraham Kolel, Hila Rushkin, Oren Tchaicheeyan, Ayelet Lesman

Annals of Biomedical Engineering. 2019


Mechanical Interaction between Cells Facilitates Molecular Transport

David Gomez, Sari Natan, Yair Shokef, Ayelet Lesman

Advanced Biosystems. 2019


Force Chains in Cell-Cell Mechanical Communication

Amots Mann, Ran S. Sopher, Shahar Goren, Ortal Shelah, Oren Tchaicheeyan, Ayelet Lesman

Journal of the Royal Society Interface. 2019


Nonlinear elasticity of the ECM fibers facilitates efficient intercellular communication

Ran S. Sopher, Hanan Tokash, Sari Natan, Mirit Sharabi, Ortal Shelah, Oren Tchaicheeyan, Ayelet Lesman

Biophysical Journal. 2018


Additional articles with the participation of Ayelet – prior to the formation of the lab:

Mechanical regulation of vascular network formation in engineered matrices

Ayelet Lesman, Dekel Rosenfeld-Dado, Shira Landau, Shulamit Levenberg​

Advanced Drug Delivery Reviews. 2015

Quantifying cell-induced matrix deformation in three dimensions based on imaging matrix fibers

Jacob Notbohm, Ayelet Lesman, David A. Tirrell, Guruswami Ravichandran​​

Integrative Biology. 2015

Microbuckling of fibrin provides a mechanism for cell mechanosensing

Jacob Notbohm, Ayelet Lesman, Phoebus Rosakis, David A. Tirrell, Guruswami Ravichandran​

Journal of the Royal Society Interface. 2015

Contractile forces regulate cell division in three-dimensional environments. Journal of Cell Biology

Ayelet Lesman, Jacob Notbohm, David A. Tirrell, Guruswami Ravichandran​

Journal of Cell Biology. 2014 

Engineering vessel-like networks within multicellular fibrin-based constructs

Ayelet Lesman, Jacob Koffler, Roee Atlas, Yaron Blinder, Zvi Kam, Shulamit Levenberg

Biomaterials. 2011

Modeling of flow-induced shear-stress within 3D cellular scaffold; Implications for vascular tissue-engineering. Biotechnology and Bioengineering

Ayelet Lesman, Yaron Blinder, Shulamit Levenberg​

Biotechnology and Bioengineering. 2010

Transplantation of tissue-engineered human vascularized cardiac muscle

Ayelet Lesman, Manhal Habib, Amira Gepstein, Gil Arbel, Shulamit Levenberg and Lior Gepstein​

Tissue Engineering Part A. 2010

Vascularization shaping the heart

Ayelet Lesman, Lior Gepstein, Shulamit Levenberg​

Annals of the New York Academy of Sciences. 2010

Vascularization; The candidate to viable engineered tissue

Tamar Kully, Keren Francis, Ayelet Lesman, Shulamit Levenberg​

Tissue Engineering Part B: Reviews. 2009

Tissue engineering of vascularized cardiac muscle from human embryonic stem cells

Oren Caspi, Ayelet Lesman, Yaara Basevitch, Amira Gepstein, Gil Arbel, Manhal Habib, Lior Gepstein and Shulamit Levenberg​

Circulation Research. 2007

Oxide formation on low modulus Ti45Nb alloy by anodic versus thermal Oxidation

Gilad Zorn, Ayelet Lesman, Irena Gotman​

Surface and Coatings Technology. 2006

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